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Atomic subtyping of malignant growth is a significant toward a few individualized treatment and gives huge natural close dependent on disease heterogeneity. In spite of the fact that quality articulation depending arrangement has been broadly shown to be a fruitful calculation in the ongoing years, the broad experimentation has for quite some time been limited by means of stage variety, bunch impacts, and the issue to classify every patients. Profound Flexible Neural Forest (DFNForest) model is presented, a novel troupe of Flexible Neural Tree (FNT) has been acquainted as of late with unravel this issue and which have been applied to disease subtypes order. Choice of qualities in these examples turns into a significant assignment for quality articulation information. The fluctuated multifaceted nature of a few tumors makes this assignment is still issue. In this paper, a novel transformative relying upon Modified Cuckoo Search (MCS) is acquainted with pick the significant qualities for malignancy subtype arrangement. Utilize MCS calculation with Neighborhood Rough Set (NRS) is utilized to pick most valuable qualities between a quality articulation dataset. The MCS is utilized to eliminate immaterial qualities and afterward NRS is applied to diminish repetitive qualities. MCS - NRS calculation is presented for dimensionality decrease of quality articulation information to build arrangement results. Course structure of DFNForest is acquainted with grow the FNT model thus with the end goal of the profundity of the model is expanded excluding setting up extra boundaries. The proposed MCS - NRS based DFNForest classifier works in a way that is better than different classifiers, for example, Artificial Neural Network (ANN) and multi-grained course Forest (gcForest). Results got higher characterization exactness, f-measure when contrasted and other widely utilized classifiers (gcForest and ANN).