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People are our most valuable asset, and Human Resource Management (HRM) plays a critical role in organizations that influences performance quality. Adopting a high-performance work system is gaining popularity since data shows that organizations that implement such systems, particularly in hospitals, have had great success. The effects of high-performance work systems (HPWS) on nurses' performance are investigated in this paper. This paper suggests that (HPWS) can improve performance by moderating the role of job stress. Since high-performance work systems, job stress, and nurse performance in Jordanian hospitals, it will be fascinating to see if the outstanding results can be translated to the service industry. The research findings of high-performance work systems in hospitals are explored in this conceptual study. For research reasons, this paper may be useful to people interested in studying the phenomenon of high-performance work systems, job stress, and nurses' performance in hospitals. Also, by expanding and combining explanations and predictions of HPWS and work stress, two topics that have generally been examined independently of one another, this work opens up new research options. There are implications for practice as well as directions for future research.