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Congenital heart disease is a significant cause of morbidity death in children. Pulse oximetry is used routinely in neonatal intensive care and emergency departments. This study evaluates the results of oxygen saturation measured by pulse oximetry to detect congenital heart disease in children. This research is a cross-sectional, comparative study. We involved 72 participants. In-depth studies were carried out at several mater-nity and pediatric hospitals in Indonesia from September 2020 to March 2021. Children suspected of having congenital heart disease were examined by echocardiography and pulse oximetry together. Oxygen saturation limit (Spo2) measured by pulse oximetry below 95% was considered low and compared with echocardiography results. The sensitivity, specificity, false-positive rate, false-negative rate, predictive value, and accuracy rate are also calculated. Ninety-five children have registered. 45 (47%) had congenital heart disease, and 50 children (53%) had average echocardiography results. Pulse oximetry showed decreased Spo2 in 13 of 45 children with congenital heart disease (sensitivity = 29%) and generally in 44 of 50 children (specificity = 88%). The results were somewhat similar after comparing the Spo2 results of children with Asiatic congenital heart disease versus normal children. Spo2 of cyanotic congenital heart disease in normal group children showed high sensitivity and specificity, 100% & 88%, respectively. Pulse oximetry was found to be a specific & sensitive tool for detecting cyanotic defects. The routine use of pulse oximetry can detect congenital heart disease in children that other tools may not detect.