Effect of Fumaric Acid on Rabbits

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Gulnaz Sh. Zakirova, Svetlana N. Potapova, Ilnur R. Kadikov, Iskander F. Vafin, Andrey A. Korchemkin, Raphael U. Biktashev, Andrey I. Samsonov, Airat M. Idrisov, Timur R. Gaуnutdinov, Sergey Yu. Smolentsev, Natalya K. Romanova


One of the ways to increase animal productivity is the use of biologically active substances, organic acids, in feeding technology. The aim of our study was to investigate the effects of different doses of dietary fumaric acid on rabbits. For that purpose, 20 Chinchilla rabbits (1700-1900 g) of both sexes were randomly allocated into five groups of 5 animals each: group 1 - a biological control group that received vegetable oil (solvent) orally 3ml/head; groups 2, 3 and 4 received fumaric acid at a dose of 1/10 of LD50 (1 3 g/kg), 1/20 of LD50 (0.65 g/kg) and 1/50 of LD50 (0.26 g/kg), respectively. Thus it was found that the addition of fumaric acid in the above doses to the diet of rabbits for 30 days, has a small stimulating effect on growth of live weight and enhances the antioxidant properties of the body, while not causing significant changes in the parameters of general and biochemical analysis of blood, meat quality and internal organs of rabbits.

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