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In this paper, it was wanted to verify the clinical applicability of a physical-mathematical methodology developed in the context of probability theory and entropy S/k proportions to evaluate antepartum cardiotocography in 20 minutes. For this, 100 cardiotocography records were collected from women in the last trimester of gestation, the values of the minimum and maximum fetal heart rate were taken for 10 seconds, the number of repetitions of each frequency, the values of its probability and the values of the S/k proportions. To verify the diagnostic capacity of the methodology, the sensitivity, specificity, and the Kappa coefficient of the physical-mathematical method were calculated with respect to the clinical gold standard by means of a blind study. It was found for the reactive tracings, values of the S/k proportions between -1.9603 to -1.7125 were obtained, while for the non-reactive traces these values ranged from -2.3838 to -1.0576. The sensitivity and specificity values were 100% and the Kappa coefficient was 1. Thus, it was concluded that the clinical applicability of a physical-mathematical methodology that can diagnose reactive from non-reactive cardiotocography traces in 20 minutes was verified, suggesting its diagnostic utility in real time.